Tell your doctor or dentist that you take carbidopa and levodopa before you receive any medical or dental care, emergency care, or surgery. Sinemet CR: A version of Sinemet that works for a longer period of time as it releases the drug more slowly into the body. Miller RD. Pharmacodynamics and pharmacokinetics of anticholinesterase. In: Ruegheimer E, Zindler M, ed. Anaesthesiology. Hamburg, Germany: Congress; Sep 14-21, 1980; 222-223. avodart
Cronnelly R, Stanski DR, Miller RD, Sheiner LB. Pyridostigmine kinetics with and without renal function. Clin Pharmacol Ther. Miscellaneous: Faintness, hoarseness, malaise, hot flashes, sense of stimulation, bizarre breathing patterns. In rare cases, the vein may become inflamed after the blood sample is taken. This condition is called and is usually treated with a warm compress applied several times daily. These may be symptoms of a serious medical problem and should be checked by a doctor. Depending on the symptoms being treated, you may need to contact your doctor earlier than 1 week, if they persist or worsen. Check your specific package label for when to contact your doctor.
Because both therapeutic and adverse responses occur more rapidly with SINEMET than with levodopa alone, patients should be monitored closely during the dose adjustment period. Specifically, involuntary movements will occur more rapidly with SINEMET than with levodopa. The occurrence of involuntary movements may require dosage reduction. Blepharospasm may be a useful early sign of excess dosage in some patients. Most importantly - I think this is a problem you can manage with a focused conversation with your neurologist. I think she has a good concept of PD treatment. In addition, the beneficial effects of levodopa in Parkinson's disease have been reported to be reversed by phenytoin and papaverine. Patients taking these drugs with Carbidopa and Levodopa extended-release should be carefully observed for loss of therapeutic response.
Dyskinesia: Abnormal muscle movements. May appear as a side effect of long-term drug treatment in Parkinson's and may worsen in response to stress. Following Carbidopa and Levodopa extended-release, the apparent half-life of levodopa may be prolonged because of continuous absorption. The usual form of Parkinson's is idiopathic Parkinson's.
Paraesthesia: Sensations, usually unpleasant, arising spontaneously in a limb or other part of the body, experienced as "pins and needles" or fluctuations of warmth or coldness. Body as a Whole: Asthenia, fatigue, abdominal pain, orthostatic effects. Requip may cause hallucinations the sensation of hearing or seeing something that is not there most commonly among elderly people. Call your doctor if you experience hallucinations. There are no risks associated with collecting a urine sample. PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of taking carbidopa and levodopa while you are pregnant. Carbidopa and levodopa is found in breast milk. If you are or will be breast-feeding while you are taking carbidopa and levodopa, check with your doctor. Discuss any possible risks to your baby. Cassettes should be protected from light and kept in carton prior to use. There have been reports of patients experiencing intense urges to gamble, increased sexual urges, and other intense urges, and the inability to control these urges while taking one or more of the medications that increase central dopaminergic tone and that are generally used for the treatment of Parkinson's disease, including Carbidopa and Levodopa extended-release. Although it is not proven that the medications caused these events, these urges were reported to have stopped in some cases when the dose was reduced or the medication was stopped. Prescribers should ask patients about the development of new or increased gambling urges, sexual urges or other urges while being treated with Carbidopa and Levodopa extended-release. Patients should inform their physician if they experience new or increased gambling urges, increased sexual urges, or other intense urges while taking Carbidopa and Levodopa extended-release. It may be necessary to increase the dose of Ativan in female patients who are concomitantly taking oral contraceptives. Keep at least one hand free at all times; try using a backpack or fanny pack to hold things rather than carrying them in your hands. Never carry objects in both hands when walking as this interferes with balance. Published studies in animals demonstrate that the use of anesthetic agents during the period of rapid brain growth or synaptogenesis results in widespread neuronal and oligodendrocyte cell loss in the developing brain and alterations in synaptic morphology and neurogenesis. Based on comparisons across species, the window of vulnerability to these changes is believed to correlate with exposures in the third trimester through the first several months of life, but may extend out to approximately 3 years of age in humans. Originally published April 1, 2003. Gastrointestinal: Taste alterations, dark saliva. RLS makes if difficult to fall asleep and may also awaken you out of sleep, forcing you to walk around to relieve the discomfort. Though not considered medically serious, symptoms of RLS can range from bothersome to having a severe impact on you and your bed partner's lives. The dosage is based on your medical condition and response to treatment. Keep all regular medical and laboratory appointments. Sustention or postural tremor: Tremor that increases when hands are stretched out in front.
These are a range of practices and environmental factors, many of which are under your control. Tablets, are available as white, flat-faced tablets containing 60 mg pyridostigmine bromide in bottles of 100 NDC 0187-3010-30 and 500 NDC 0187-3010-40. Each tablet is engraved "Mestinon 60 V" on one side and is quadrisect scored on the other. Studies in 6 healthy young adults who received lorazepam injection and no other drugs revealed that visual tracking the ability to keep a moving line centered was impaired for a mean of 8 hours following administration of 4 mg of intramuscular lorazepam and 4 hours following administration of 2 mg intramuscularly with considerable subject variation. Similar findings were noted with pentobarbital, 150 and 75 mg. Although this study showed that both lorazepam and pentobarbital interfered with eye-hand coordination, the data are insufficient to predict when it would be safe to operate a motor vehicle or engage in a hazardous occupation or sport. Attempt to swing both arms from front to back while walking. Palilalia: A symptom of Parkinson's disease, in which a word or syllable is repeated and the flow of speech is interrupted. Lorazepam interacts with the γ-aminobutyric acid GABA-benzodiazepine receptor complex, which is widespread in the brain of humans as well as other species. Carbidopa helps prevent the breakdown of levodopa before it can reach the brain and take effect. Patients taking Carbidopa and Levodopa extended-release alone or with other dopaminergic drugs have reported suddenly falling asleep without prior warning of sleepiness while engaged in activities of daily living includes operation of motor vehicles. Road traffic accidents attributed to sudden sleep onset have been reported. Although many patients reported somnolence while on dopaminergic medications, there have been reports of road traffic accidents attributed to sudden onset of sleep in which the patient did not perceive any warning signs, such as excessive drowsiness, and believed that they were alert immediately prior to the event. Sudden onset of sleep has been reported to occur as long as one year after the initiation of treatment. naproxen
Do not start, stop, or change the dosage of any medicines without your doctor's approval. Ask your doctor if you should have regular skin exams. Avoid taking iron supplements or eating a diet that is high in protein protein sources include meat, eggs, and cheese. These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication. Collect a urine sample in a clean container. Problems with also occur in the later stages of PSP. Usually, visual problems can become as much of an issue as impaired walking for the patient. is most affected by the difficulty to aim the properly, making reading very hard. Another problem that is sometimes encountered is the inability to maintain visual contact with another person during conversation. Therefore, not use this product to treat in children younger than 6 years unless specifically directed by the doctor. One procedure, called uvulopalatopharyngoplasty, removes tissue at the back of the throat. In addition to having low success rates of between 30%-60%, it is difficult to predict exactly which patients will benefit, as well as the long-term outcome and side effects. IV administration of 50 mg levodopa with carbidopa 50 mg. Store at room temperature in a tightly closed container away from light and moisture. not store in the bathroom. Keep all away from children and pets. The daily dosage of Carbidopa and Levodopa extended-release must be determined by careful titration. Patients should be monitored closely during the dose adjustment period, particularly with regard to appearance or worsening of involuntary movements, dyskinesias or nausea. Carbidopa and Levodopa extended-release tablets should not be chewed or crushed. Initial dosage should not be given at intervals of less than 6 hours. Sinemet is also used to treat Parkinson symptoms caused by or manganese intoxication. Sinemet is available in generic form. generic furadantin description furadantin
The beginning stages of PSP include the inability to walk, falling spells, and stiffness. Data from all randomized patients were used in this test. Symptoms may include depression; difficulty breathing; dilated or sluggish pupils; dry skin; fast breathing; fast heartbeat; high blood pressure; hot, dry, flushed skin. Diabetes patients - Carbidopa and levodopa may cause the results of some tests for urine glucose or urine ketones to be wrong. Ask your doctor before you change your diet or the dose of your diabetes medicine. Taste alterations, dark saliva. risperdal prices australia
One hundred and thirty 130 patients received Ativan Injection. Totals are not necessarily the sum of the individual study events because a patient may report two or more different study events in the same body system. Suggested dose for patients receiving less than levodopa 1500 mg per day: 25 mg-100 mg orally 3 or 4 times a day. Cryothalamotomy: A surgical procedure where a "super-cooled" probe is inserted deep into the part of the brain called the thalamus in an effort to stop the tremors of Parkinson's. This type of surgery is rarely recommended and has been replaced by deep brain stimulation DBS. Propulsive gait: Disturbance of gait typical of people with symptoms of Parkinson's in which, during walking, steps become faster and faster with progressively shorter steps that passes from a walking to a running pace and may precipitate falling forward. There are no ketones in your blood or urine. There are both behavioral treatments and medications for this situation, which can make life livable again. Epidemiological studies have shown that patients with Parkinson's disease have a higher risk 2- to approximately 6-fold higher of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson's disease or other factors, such as drugs used to treat Parkinson's disease, is unclear. Carbidopa and Levodopa extended-release should be administered cautiously to patients with severe cardiovascular or pulmonary disease, bronchial asthma, renal, hepatic or endocrine disease. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Carbidopa and Levodopa extended-release tablets are designed in a drug delivery system that controls the release of Carbidopa and Levodopa as it slowly erodes. Sinemet low. I have had her lower requip and taught mysellf when to take it best. My only unbearable symptom is the peripheral neurapathy heebie geebies! Some medical conditions may interact with carbidopa and levodopa. Gradually increase physical activity as your symptoms improve. Treatment of overdosage is mainly supportive until the drug is eliminated from the body. Vital signs and fluid balance should be carefully monitored in conjunction with close observation of the patient. An adequate airway should be maintained and assisted respiration used as needed. With normally functioning kidneys, forced diuresis with intravenous fluids and electrolytes may accelerate elimination of benzodiazepines from the body. In addition, osmotic diuretics, such as mannitol, may be effective as adjunctive measures. In more critical situations, renal dialysis and exchange blood transfusions may be indicated. Lorazepam does not appear to be removed in significant quantities by dialysis, although lorazepam glucuronide may be highly dialyzable. The value of dialysis has not been adequately determined for lorazepam. Administered into the jejunum through a PEG-J tube using a CADD-Legacy 1400 portable infusion pump; for short term administration, a naso-jejunal tube may be used. The blood sample is taken from a vein in your arm. An elastic band is wrapped around your upper arm. It may feel tight. You may feel nothing at all from the needle, or you may feel a quick sting or pinch.
Standard drugs for Parkinson's disease, other than levodopa without a decarboxylase inhibitor, may be used concomitantly while Carbidopa and Levodopa extended-release is being administered, although their dosage may have to be adjusted. Physical or mechanical therapies only work at the time they are properly used. Apnea episodes return when they are not utilized. Pediatric patients as well as adults with atypical petit mal status epilepticus have developed brief tonic-clonic seizures shortly after Ativan was given. This “paradoxical” effect was also reported for diazepam and clonazepam. Home blood sugar meters that also test for ketones display results on the meter's screen. This is more likely when you are first starting the medication or when your dose is increased, or when you get up suddenly. To lower your risk, get up slowly from a sitting or lying position. Do not use with any other applied to the such as diphenhydramine cream, ointment, spray because increased side effects may occur. generic aggrenox comp
This is not harmful but may discolor clothing. Grob D. Myasthenia gravis. A review of pathogenesis and treatment. Arch Intern Med. Waking after seven to eight hours of sleep and feeling unrefreshed could be a sign of poor quality sleep. The quality of sleep is as vitally important to our health and well-being as is the quantity. Our sleep has a complex pattern, or architecture, consisting of four stages that run through various cycles during the night. During certain stages and times of the sleep cycle, we secrete a variety of hormones and other substances that help regulate our and other health-related factors. If our sleep patterns are altered, it may leave us feeling unrefreshed, tired, and sleepy, as well as put us at risk for a host of serious medical conditions. In the past, these drugs were used to treat some of the symptoms of Parkinson's. Beta-blockers: Drugs that block the action of the hormone epinephrine. Cerebral cortex: The largest part of the brain, responsible for thought, reasoning, memory, sensation, and voluntary movement. Cardiovascular: Monitor for signs and symptoms of orthostatic hypotension, particularly during dose escalation; for patients with a history of myocardial infarction with residual atrial, nodal, or ventricular arrhythmias, cardiac function should be monitored in an intensive cardiac care facility during drug initiation. Geriatric: A study in eight young healthy subjects 21 to 22 yr and eight elderly healthy subjects 69 to 76 yr showed that the absolute bioavailability of levodopa was similar between young and elderly subjects following oral administration of levodopa and carbidopa. However, the systemic exposure AUC of levodopa was increased by 55% in elderly subjects compared to young subjects. Patients should be carefully monitored for signs and symptoms of neuroleptic malignant syndrome if treatment is abruptly reduced or discontinued. The size and frequency of the dosage must be adjusted to the needs of the individual patient. Carbidopa inhibits decarboxylation of peripheral levodopa. price rifampicin through medco rifampicin
If you have bleeding or clotting problems, or if you take blood-thinning medicine, tell your health professional before your blood is drawn. L200' on one side and breakline on other. Festination: Walking in rapid, short, shuffling steps. The prescriber should be aware that these figures cannot be used to predict the frequency of adverse events in the course of usual medical practice where patient characteristics and other factors may differ from those prevailing during clinical studies. Similarly, the cited frequencies cannot be directly compared with figures obtained from other clinical investigators involving different treatment, uses, or investigators. An inspection of these frequencies, however, does provide the prescribing physician with one basis to estimate the relative contribution of drug and nondrug factors to the adverse event incidences in the population studied. Store in a tightly closed container at room temperature between 59-86 degrees F 15-30 degrees C away from light and moisture. not store in the bathroom. Nonselective monoamine oxidase MAO inhibitors are contraindicated for use with Carbidopa and Levodopa extended-release. These inhibitors must be discontinued at least two weeks prior to initiating therapy with Carbidopa and Levodopa extended-release. When trying to navigate turns, use a "U" technique of facing forward and making a wide turn, rather than pivoting sharply. It may take up to several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve. What Are Some of the Later Symptoms of PSP? The adverse clinical events most commonly observed with the use of Ativan Injection in clinical trials evaluating its use in status epilepticus were hypotension, somnolence, and respiratory failure. Maximum daily dose: 612. Levodopa should be discontinued at least 12 hours before starting carbidopa-levodopa; initiate with approximately 25% of the previous levodopa dose. The side effects of Mestinon are most commonly related to overdosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication. Inform your doctor if your condition does not improve or if it worsens. Lab tests may be performed while you use Sinemet. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. SINEMET CR is started. topiramate
Postural tremor: Tremor that increases when hands are stretched out in front. NDC 0006-3916-68 bottles of 100. Intramuscular injection of lorazepam has resulted in pain at the injection site, a sensation of burning, or observed redness in the same area in a very variable incidence from one study to another. Patients with chronic wide-angle glaucoma may be treated cautiously with Carbidopa and Levodopa extended-release provided the intraocular pressure is well-controlled and the patient is monitored carefully for changes in intraocular pressure during therapy. In primates, exposure to 3 hours of ketamine that produced a light surgical plane of anesthesia did not increase neuronal cell loss, however, treatment regimens of 5 hours or longer of isoflurane increased neuronal cell loss. Data from isoflurane-treated rodents and ketamine-treated primates suggest that the neuronal and oligodendrocyte cell losses are associated with prolonged cognitive deficits in learning and memory. The clinical significance of these nonclinical findings is not known, and healthcare providers should balance the benefits of appropriate anesthesia in pregnant women, neonates and young children who require procedures with the potential risks suggested by the nonclinical data. Postural instability: Difficulty with balance. Requip : A new drug used to treat Parkinson's. It works by increasing the amount of dopamine available in the brain. Because the kidney is the primary route of elimination of lorazepam glucuronide, renal impairment would be expected to compromise its clearance. This should have no direct effect on the glucuronidation and inactivation of lorazepam. There is a possibility that the enterohepatic circulation of lorazepam glucuronide leads to a reduced efficiency of the net clearance of lorazepam in this population. Unilateral: Occurring on one side of the body. Parkinson's disease symptoms usually begin unilaterally. Carbidopa and Levodopa. However, global ratings of improvement as assessed by both patient and physician were better during therapy with Carbidopa and Levodopa extended-release than with Carbidopa and Levodopa. In patients without motor fluctuations, Carbidopa and Levodopa extended-release, under controlled conditions, provided the same therapeutic benefit with less frequent dosing when compared to Carbidopa and Levodopa. Edema, weight gain, weight loss. Follow the manufacturer's directions on the bottle of test strips or tablets.
The safety of Ativan in pediatric patients has not been established. NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermia. Neurological findings, including muscle rigidity, involuntary movements, altered consciousness, mental status changes; other disturbances, such as autonomic dysfunction, tachycardia, tachypnea, sweating, hyper- or hypotension; laboratory findings, such as creatine phosphokinase elevation, leukocytosis, myoglobinuria, and increased serum myoglobin have been reported. Ativan Injection, active comparators, and Ativan Injection in combination with a comparator were administered to 488 individuals during controlled and open-label clinical trials. Because of reenrollments, these 488 patients participated in a total of 521 patient-episodes. Overdosage of benzodiazepines is usually manifested by varying degrees of central-nervous-system depression, ranging from drowsiness to coma. In mild cases symptoms include drowsiness, mental confusion and lethargy. In more serious examples, symptoms may include ataxia, hypotonia, hypotension, hypnosis, stages one 1 to three 3 coma, and, very rarely, death. Talk to your doctor about any concerns you have regarding the need for the test, its risks, how it will be done, or what the results will mean. To help you understand the importance of this test, fill out the What is a document? RYTARY carbidopa-levodopa extended-release capsule is not interchangeable with other carbidopa-levodopa products. No special preparation is needed before having this test. Anticholinergic drugs Artane, Cogentin: The group of drugs that decreases the action of the nerve chemical acetylcholine. These drugs may help reduce rigidity, tremor, and drooling in Parkinson's. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. Safety and effectiveness in pediatric patients have not been established. Intravenous or intramuscular administration of the recommended dose of 2 mg to 4 mg of Ativan Injection to adult patients is followed by dose-related effects of sedation sleepiness or drowsiness relief of preoperative anxiety, and lack of recall of events related to the day of surgery in the majority of patients. The clinical sedation sleepiness or drowsiness thus noted is such that the majority of patients are able to respond to simple instructions whether they give the appearance of being awake or asleep. The lack of recall is relative rather than absolute, as determined under conditions of careful patient questioning and testing, using props designed to enhance recall. The majority of patients under these reinforced conditions had difficulty recalling perioperative events or recognizing props from before surgery. The lack of recall and recognition was optimum within 2 hours following intramuscular administration and 15 to 20 minutes after intravenous injection. No dosage adjustments are needed in elderly patients and in patients with hepatic disease. As with all central-nervous-system-depressant drugs, care should be exercised in patients given injectable lorazepam as premature ambulation may result in injury from falling. This information should not be used to decide whether or not to take trihexyphenidyl or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about trihexyphenidyl. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to trihexyphenidyl. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using trihexyphenidyl. Pyridostigmine is mainly excreted unchanged by the kidney. average wholesale price for finasteride
Only immediate-release Requip is approved to treat either Parkinson symptoms or RLS. Extended-release Requip XL is approved only to treat Parkinson symptoms. Neurotransmitter: A specialized chemical produced in nerve cells that permits the transmission of information between nerve cells. Dopamine is one example. For the reasons stated above, patients and providers are advised to monitor for melanomas frequently and on a regular basis when using Carbidopa and Levodopa extended-release for any indication. If any of these effects last or get worse, tell your doctor or promptly. The possibility that a woman of childbearing potential may be pregnant at the time of therapy should be considered. When levodopa is administered orally it is rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system. For this reason, large doses of levodopa are required for adequate therapeutic effect and these may often be accompanied by nausea and other adverse reactions, some of which are attributable to dopamine formed in extracerebral tissues. Drink plenty of fluids. Immediately prior to intravenous use, Ativan Injection must be diluted with an equal volume of compatible solution. Contents should be mixed thoroughly by gently inverting the container repeatedly until a homogenous solution results. Do not shake vigorously, as this will result in air entrapment. When properly diluted, the drug may be injected directly into a vein or into the tubing of an existing intravenous infusion. Patients must be advised that the whole or half tablet should be swallowed without chewing or crushing. Parkinson's and RLS are two separate disorders. Having one of these conditions will not cause you to have the other condition. For some, following special swallowing techniques is sufficient to alleviate swallowing problems. For others, dietary changes may be necessary. How Are Swallowing Problems Diagnosed in Parkinson's Disease? Patients should be alerted to the possibility of sudden onset of sleep during daily activities, in some cases without awareness or warning signs, when they are taking dopaminergic agents, including levodopa. lolem.info clonidine
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Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. There have been rare reports of adverse reactions, including hypertension and dyskinesia, resulting from the concomitant use of tricyclic antidepressants and carbidopa levodopa preparations. buy dapsone reacoes
This medication may interfere with certain laboratory tests including urine 5-HIAA possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. Some people taking this medication have fallen asleep suddenly during their usual daily activities such as talking on the phone, driving. In some cases, sleep occurred without any feelings of drowsiness beforehand. Do not stop using Requip or change your dose without first talking to your doctor. You may have side effects such as fever, muscle stiffness, and confusion if you stop the medication suddenly or if you change doses. nizoral
Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately. glipizide order mastercard
Try to stand with your feet width apart. When your feet are close together for any length of time, you increase your risk of losing your balance and falling. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. The number indicates the number of “patient-episodes. Sporadic cases of a symptom complex resembling neuroleptic malignant syndrome NMS have been reported in association with dose reductions or withdrawal of certain antiparkinsonian agents such as levodopa, carbidopa levodopa and carbidopa levodopa extended release. Therefore, patients should be observed carefully when the dosage of levodopa is reduced abruptly or discontinued, especially if the patient is receiving neuroleptics.